Bilirubin - the molecule responsible for jaundice

Bilirubin - we often see this term. Each general blood test determines the amount of bilirubin. Why is it important to know its quantity and what does it affect? Under the cat, we will analyze this question in detail, as well as the question of why bilirubin is an endogenous antioxidant.

Bile pigment bilirubin is the main end product of heme breakdown in the liver. Hem is a component of hemoglobin that gives it a red color. Bilirubin is excreted in the bile and urine. The yellow color of the pigment is responsible for the appearance of people with jaundice.

Determination of the concentration of bilirubin in the blood is the main test for the diagnosis of hepatobiliary disease, with violations of the heart or liver, etc.

Story

In 1847, the German scientist Rudolf Virchow and his colleagues separated crystals of bilirubin from blood taken from a hematoma. More than a century later, Irving M. London and employees at Columbia University demonstrated that heme is indeed its source.

. , , 18 . 1875 , . , , .

20- , , . , . (RC=N⁺=N⁻). . , , , , . , , .

– - , . , , () ()-. .

. : 1,3--2--2- .

3-4 , , , , . (). , , . , , .

, , . . .

, 60 80 % . , ()- , - , , . - – . , , . . , ( 80 %) ( 20 %).

. , , . . , , .

(.)

,

, ,

--1 UGT1A1, , . .

• - . , . , . , - . , UGT1A1 [1].
• . PPARα, , , , , [2].
• – , , , . , . . -. [1].
  
• , . [3]
  

[3]

– , .

– 3,4 -17,1 /. 3,4 /. – 13,7 /. 27-34 /. 500 + 200 . .

?

• ,

«» – , , , . , , , (, ) .

• – . , . , , . . . , , , ( )
  
• – , . / –SH [4].
  
• – «», [5]. , .
  

• – , - , , , .
  
• .
• , , .
  
• , , .
  

Lifext ,

, . , .

Lifext.

— + .

, Google. Lifext, . ( ) + .

— 120 . ( 1,9$, ). , . - , , .

, , ;)

Lifext . , , . .

• Telegram
• Telegram
• VK
• Instagram